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Invitrogen
TIMP4 Polyclonal Antibody
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FIGURE: 1 / 1
TIMP4 Antibody (PA5-92959) in WB
Product Details
PA5-92959
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: CSCAPAHPQQ HICHSALVIR AKISSEKVVP ASADPADTEK MLRYEIKQIK MFKGFEKVKD VQYIYTPFDS SLCGVKLEAN SQKQYLLTGQ VLSDGKVFIH LCNYIEPWED LSLVQRESLN HHYHLNCGCQ ITTCYTVPCT ISAPNECLWT DWLLERKLYG YQAQHYVCMK HVDGTCSWYR GHLPLRKEFV DIVQP; Positive Samples: HT-29, Mouse heart, Mouse brain, Mouse ovary, Rat heart, Rat brain
Target Information
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and is known to inhibit the activity of matrix metalloproteinases. Matrix metalloproteinases (MMP) are a group of proteinases that degrade the components of extracellular matrix. TIMP4 irreversibly binds to MMPs and inactivates them with the help of zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological functions include response to cytokine and peptide hormone stimuli and involvement with the ovulation cycle and CNS development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Metalloproteinase inhibitor 4; TIMP 4; TIMP-4; tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4
Gene Aliases: TIMP-4; TIMP4
UniProt ID: (Human) Q99727, (Mouse) Q9JHB3, (Rat) P81556
Entrez Gene ID: (Human) 7079, (Mouse) 110595, (Rat) 680130
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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