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Invitrogen
TIMD4 Polyclonal Antibody
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Product Details
PA5-20247
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
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RRID
Product Specific Information
A suggested positive control is Jurkat cell lysate.
PA5-20247 can be used with blocking peptide PEP-0365.
Target Information
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: SMUCKLER; soluble TIM 4; Spleen, mucin-containing, knockout of lymphotoxin protein; sTIM 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; TIM-4; TIMD-4
Gene Aliases: B430010N18Rik; RGD1564516; SMUCKLER; TIM-4; TIM4; TIMD4
UniProt ID: (Human) Q96H15, (Mouse) Q6U7R4
Entrez Gene ID: (Human) 91937, (Rat) 497891, (Mouse) 276891
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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