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Proteintech
TIMD4 Polyclonal Antibody
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Product Details
12008-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: SETVVTEVL GHRVTLPCLY SSWSHNSNSM CWGKDQCPYS GCKEALIRTD GMRVTSRKSA KYRLQGTIPR GDVSLTILNP SESDSGVYCC RIEVPGWFND VKINVRLNLQ RASTTTHRTA TTTTRRTTTT SPTTTRQMTT TPAALPTTVV TTPDLTTGTP LQMTTIAVFT TANTCLSLTP STLPEEATGL LTPEPSKEGP ILTAESETVL PSDSWSSAES TSADTVLLTS KESKVWDLPS TSHVSMWKTS DSVSSPQPGA SDTAVPEQNK TTKTGQMDGI PMSMKNEMPI SQLLMIIAPS LGFVLFALFV AFLLRGKLME TYCSQKHTRL DYIGDSKNVL NDVQHGREDE DGLFTL (24-378 aa encoded by BC008988)
Target Information
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: soluble TIM 4; sTIM 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; TIM-4; TIMD-4
Gene Aliases: SMUCKLER; TIM4; TIMD4
UniProt ID: (Human) Q96H15
Entrez Gene ID: (Human) 91937
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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