Proteintech

TIAM1 Polyclonal Antibody

View all (12) TIAM1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

27694-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:600
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TIAM1 Fusion Protein Ag26777

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1200 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: human T-lymphoma invasion and metastasis inducing TIAM1 protein; Rho guanine nucleotide exchange factor TIAM1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1

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Gene Aliases: AI847750; D16Ium10; D16Ium10e; TIAM1

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UniProt ID: (Human) Q13009

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Entrez Gene ID: (Human) 7074, (Mouse) 21844

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Function(s)
receptor signaling protein activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding microtubule binding lipid binding kinase binding Rac guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding Rac GTPase binding phospholipid binding ephrin receptor binding
Process(es)
cardiac muscle hypertrophy apoptotic process cell-matrix adhesion cell migration Rac protein signal transduction positive regulation of protein binding regulation of Rho protein signal transduction response to cocaine positive regulation of apoptotic process positive regulation of JUN kinase activity ephrin receptor signaling pathway positive regulation of axonogenesis regulation of small GTPase mediated signal transduction Wnt signaling pathway, planar cell polarity pathway positive regulation of dendritic spine morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of ERK1 and ERK2 cascade protein localization to membrane activation of GTPase activity positive regulation of Schwann cell chemotaxis regulation of dopaminergic neuron differentiation neuron projection extension regulation of non-canonical Wnt signaling pathway signal transduction small GTPase mediated signal transduction positive regulation of neuron projection development brain-derived neurotrophic factor receptor signaling pathway intracellular signal transduction regulation of GTPase activity positive regulation of GTPase activity
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