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  • TGFBR1 Antibodies

AbboMax

TGFBR1 Polyclonal Antibody

View all (21) TGFBR1 antibodies

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Datasheet
Protocols
Questions & Answers

Cite TGFBR1 Polyclonal Antibody

  • Antibody Testing Data (1)
TGFBR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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TGFBR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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TGFBR1 Antibody (630-290) in IHC (P)

Immunohistochemistry: Human placenta (FFPE) stained with Rabbit anti-TGFbR1 (Cat# 630-290) at 1:100 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TGFBR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Details

630-290

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This antibody was obtained from the depletion column of the following three Non-Phosphospecific peptides (IYDM-T-T-SGS-;-DMTT-S-G-S-G-S-GLPL-;-EEDP-S-LDRPFI)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: MCF7

Cellular location: Membrane, cytoplasm.

Target Information

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I

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Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

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UniProt ID: (Human) P36897, (Rat) P80204, (Mouse) Q64729

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Entrez Gene ID: (Human) 7046, (Rat) 29591, (Mouse) 21812

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Function(s)
protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor signaling protein activity type II transforming growth factor beta receptor binding protein binding ATP binding growth factor binding SMAD binding metal ion binding transforming growth factor beta binding I-SMAD binding ubiquitin protein ligase binding protein complex binding protein heterodimerization activity nucleotide binding transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
activation of MAPKK activity skeletal system development angiogenesis response to hypoxia in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lens development in camera-type eye regulation of transcription, DNA-templated protein phosphorylation apoptotic process signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development embryo implantation aging positive regulation of cell proliferation germ cell migration male gonad development response to toxic substance post-embryonic development anterior/posterior pattern specification regulation of gene expression positive regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation response to organic cyclic compound peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation collagen fibril organization positive regulation of cell growth lung development organ regeneration regulation of protein ubiquitination negative regulation of chondrocyte differentiation activin receptor signaling pathway response to prostaglandin E intracellular signal transduction regulation of growth endothelial cell activation negative regulation of apoptotic process regulation of protein binding endothelial cell migration response to estrogen negative regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated protein autophosphorylation thymus development digestive tract development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility positive regulation of cellular component movement positive regulation of filopodium assembly response to electrical stimulus positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development cell cycle arrest positive regulation of epithelial to mesenchymal transition positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway wound healing extracellular structure organization positive regulation of stress fiber assembly regulation of cardiac muscle cell proliferation ventricular septum morphogenesis coronary artery morphogenesis positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly embryo development phosphorylation cell differentiation
It has to be done as per old AB suggested Products section.
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