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  • Primary Antibodies ›
  • TGF beta-2 Antibodies

OriGene

TGFB2 Polyclonal Antibody

View all (17) TGF beta-2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite TGFB2 Polyclonal Antibody

  • Antibody Testing Data (2)
TGFB2 Antibody in Western Blot (WB)
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TGFB2 Antibody in Western Blot (WB)
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FIGURE: 1 / 2

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TGFB2 Antibody (TA890046) in WB

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TGFB2(RC212624, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TGFB2 r. Positive lysates LY401115 (100 µg) and LC401115 (20 µg) can be purchased separately from OriGene. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TGFB2 Antibody in Western Blot (WB)
TGFB2 Antibody in Western Blot (WB)

Product Details

TA890046

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein of human TGFB2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; polyergin; prepro-transforming growth factor beta-2; TGF-beta-2; TGFB; TGFβ2; Transforming growth factor; transforming growth factor beta-2; Transforming growth factor beta-2 proprotein; transforming growth factor, beta 2

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Gene Aliases: BB105277; LDS4; TGF-beta2; Tgfb-2; TGFB2

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UniProt ID: (Human) P61812, (Mouse) P27090

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Entrez Gene ID: (Human) 7042, (Mouse) 21808

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Function(s)
beta-amyloid binding receptor signaling protein serine/threonine kinase activity receptor binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type III transforming growth factor beta receptor binding protein homodimerization activity protein heterodimerization activity protein N-terminus binding
Process(es)
cell morphogenesis skeletal system development cartilage condensation blood vessel development eye development response to hypoxia epithelial to mesenchymal transition hair follicle development blood vessel remodeling heart morphogenesis outflow tract morphogenesis heart valve morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis protein phosphorylation cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus axon guidance heart development cell death positive regulation of cell proliferation negative regulation of cell proliferation glial cell migration cardioblast differentiation positive regulation of gene expression positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production positive regulation of phosphatidylinositol 3-kinase signaling cell growth cell migration signal transduction by protein phosphorylation hemopoiesis extracellular matrix organization collagen fibril organization positive regulation of cell growth negative regulation of cell growth positive regulation of cell migration hair follicle morphogenesis activation of protein kinase activity response to progesterone positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production positive regulation of cell adhesion mediated by integrin intracellular signal transduction growth wound healing regulation of cell proliferation dopamine biosynthetic process response to drug catagen regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of MAPK cascade positive regulation of neuron apoptotic process response to estrogen cell-cell junction organization negative regulation of keratinocyte differentiation positive regulation of integrin biosynthetic process positive regulation of cell cycle positive regulation of heart contraction somatic stem cell division neuron fate commitment neuron development embryonic neurocranium morphogenesis negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of immune response negative regulation of release of sequestered calcium ion into cytosol positive regulation of cell division positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction ventricular septum morphogenesis negative regulation of cartilage development positive regulation of activation-induced cell death of T cells extrinsic apoptotic signaling pathway regulation of extracellular matrix organization positive regulation of extrinsic apoptotic signaling pathway in absence of ligand angiogenesis platelet degranulation outflow tract septum morphogenesis membranous septum morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis cell-cell signaling salivary gland morphogenesis cell proliferation response to wounding embryo development negative regulation of gene expression neutrophil chemotaxis regulation of actin cytoskeleton organization ascending aorta morphogenesis odontogenesis uterine wall breakdown positive regulation of ossification negative regulation of Ras protein signal transduction embryonic digestive tract development generation of neurons positive regulation of immune response face morphogenesis atrial septum morphogenesis pharyngeal arch artery morphogenesis positive regulation of extracellular matrix disassembly positive regulation of protein localization to nucleus regulation of apoptotic process involved in outflow tract morphogenesis regulation of complement-dependent cytotoxicity positive regulation of GTP binding negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
It has to be done as per old AB suggested Products section.
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