TGF-beta (Transforming Growth Factor beta) Monoclonal Antibody (1D11.16.8)

glycoprotein binding antigen binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding protein homodimerization activity protein serine/threonine kinase activator activity protein heterodimerization activity protein N-terminus binding beta-amyloid binding receptor signaling protein serine/threonine kinase activity receptor binding identical protein binding transforming growth factor beta binding

protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter MAPK cascade regulation of cell growth ureteric bud development response to hypoxia morphogenesis of a branching structure cell activation epithelial to mesenchymal transition negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of sodium ion transport chondrocyte differentiation hematopoietic progenitor cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains tolerance induction to self antigen protein phosphorylation protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process cellular calcium ion homeostasis inflammatory response cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly SMAD protein import into nucleus negative regulation of neuroblast proliferation salivary gland morphogenesis endoderm development female pregnancy aging negative regulation of DNA replication cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration response to radiation response to wounding response to glucose defense response to fungus, incompatible interaction response to organic substance positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production response to organic cyclic compound cell growth regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus negative regulation of cell-cell adhesion hyaluronan catabolic process T cell differentiation negative regulation of ossification negative regulation of cell growth lung development positive regulation of cell migration positive regulation of bone mineralization mammary gland development positive regulation of histone deacetylation organ regeneration positive regulation of protein complex assembly positive regulation of exit from mitosis lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process response to estradiol response to progesterone positive regulation of interleukin-17 production receptor catabolic process positive regulation of superoxide anion generation mononuclear cell proliferation positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation response to vitamin D response to laminar fluid shear stress positive regulation of histone acetylation positive regulation of protein dephosphorylation wound healing T cell activation regulation of cell proliferation negative regulation of T cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus positive regulation of odontogenesis response to drug myelination myeloid dendritic cell differentiation T cell homeostasis positive regulation of apoptotic process positive regulation of MAP kinase activity regulation of MAPK cascade protein kinase B signaling positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling regulatory T cell differentiation cell-cell junction organization negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development inner ear development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of phagocytosis negative regulation of immune response negative regulation of T cell activation positive regulation of chemotaxis positive regulation of NF-kappaB transcription factor activity regulation of binding regulation of DNA binding positive regulation of smooth muscle cell differentiation negative regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling face morphogenesis frontal suture morphogenesis pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis negative regulation of gene silencing by miRNA regulation of cartilage development lens fiber cell differentiation response to cholesterol positive regulation of cell cycle arrest cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis extrinsic apoptotic signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity regulation of actin cytoskeleton reorganization regulation of miRNA metabolic process positive regulation of transcription regulatory region DNA binding connective tissue replacement involved in inflammatory response wound healing platelet degranulation Notch signaling pathway positive regulation of vascular endothelial growth factor production negative regulation of extracellular matrix disassembly macrophage derived foam cell differentiation oligodendrocyte development cell migration regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of interleukin-23 production negative regulation of interleukin-17 production regulation of apoptotic process positive regulation of vascular permeability positive regulation of regulatory T cell differentiation negative regulation of cell differentiation active induction of host immune response by virus positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division regulation of blood vessel remodeling regulation of SMAD protein import into nucleus positive regulation of extracellular matrix assembly positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor clustering regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of cardiac muscle cell differentiation activation of MAPK activity in utero embryonic development odontogenesis uterine wall breakdown negative regulation of neuron apoptotic process response to estrogen positive regulation of DNA replication lung alveolus development embryonic neurocranium morphogenesis positive regulation of filopodium assembly positive regulation of stress fiber assembly palate development detection of hypoxia positive regulation of occluding junction disassembly cell morphogenesis cartilage condensation angiogenesis eye development hair follicle development blood vessel remodeling heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis cell-cell signaling axon guidance heart development cell death glial cell migration embryo development cardioblast differentiation positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling signal transduction by protein phosphorylation hemopoiesis collagen fibril organization positive regulation of cell growth neutrophil chemotaxis hair follicle morphogenesis activation of protein kinase activity positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin ascending aorta morphogenesis dopamine biosynthetic process catagen positive regulation of neuron apoptotic process positive regulation of integrin biosynthetic process positive regulation of ossification positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction somatic stem cell division embryonic digestive tract development neuron fate commitment neuron development generation of neurons positive regulation of immune response positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly regulation of apoptotic process involved in outflow tract morphogenesis regulation of complement-dependent cytotoxicity positive regulation of GTP binding negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand cell development skeletal system development blood vessel development outflow tract morphogenesis cardiac left ventricle morphogenesis extracellular matrix organization intracellular signal transduction growth negative regulation of apoptotic process negative regulation of keratinocyte differentiation regulation of extracellular matrix organization organ morphogenesis regulation of epithelial cell differentiation regulation of endothelial cell differentiation regulation of epithelial cell proliferation kidney development skeletal muscle tissue development response to cold response to organonitrogen compound thyroid gland development hindbrain development pancreas development response to retinoic acid response to cytokine CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment defense response regulation of gene expression regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation T-helper 17 cell lineage commitment apoptotic process activation-induced cell death of T cells menstrual cycle phase