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NeoBiotechnologies
TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody (MF9)
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Product Details
7039-MSM1-P0
Species Reactivity
Host/Isotype
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Type
Clone
Immunogen
Conjugate
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Target Information
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Protransforming growth factor alpha; TGF a; TGF α; TGF-alpha; TGFalpha; TGFα; Transforming growth factor; transforming growth factor, alpha; transforming growth factor-alpha; waved 1
Gene Aliases: RATTGFAA; TFGA; TGFA; TGFAA; wa-1; wa1
UniProt ID: (Human) P01135, (Mouse) P48030, (Rat) P01134
Entrez Gene ID: (Human) 7039, (Mouse) 21802, (Rat) 24827
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