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Abnova
TFRC Monoclonal Antibody (2A4)
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Product Details
H00007037-M09
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
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Product Specific Information
Immunogen sequence: CKGVEPKTEC ERLAGTESPV REEPGEDFPA ARRLYWDDLK RKLSEKLDST DFTGTIKLLN ENSYVPREAG SQKDENLALY VENQFREFKL SKVWRDQHFV KIQVKDSAQN SVIIVDKNGR LVYLVENPGG YVAYSKAATV TGKLVHANFG TKKDFEDLYT PVNGSIVIVR AGKITFAEKV ANAESLNAIG VLIYMDQTKF PIVNAELSFF GHAHLGTGDP YTPGFPSFNH TQFPPSRSSG LPNIPVQTIS RAAAEKLFGN MEGDCPSDWK TDSTCRMVTS ESKNVKLTVS NVLKEIKILN IFGVIKGFVE PDHYVVVGAQ RDAWGPGAAK SGVGTALLLK LAQMFSDMVL KDGFQPSRSI IFASWSAGDF GSVGATEWLE GYLSSLHLKA FTYINLDKAV LGTSNFKVSA SPLLYTLIEK TMQNVKHPVT GQFLYQDSNW ASKVEKLTLD NAAFPFLAYS GIPAVSFCFC EDTDYPYLGT TMDTYKELIE RIPELNKVAR AAAEVAGQFV IKLTHDVELN LDYERYNSQL LSFVRDLNQY RADIKEMGLS LQWLYSARGD FFRATSRLTT DFGNAEKTDR FVMKKLNDRV MRVEYHFLSP YVSPKESPFR HVFWGSGSHT LPALLENLKL RKQNNGAFNE TLFRNQLALA TWTIQGAANA LSGDVWDIDN EF
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD antigen CD71; CD71; p90; T9; TR; Transferrin receptor protein 1
Gene Aliases: CD71; IMD46; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) P02786
Entrez Gene ID: (Human) 7037
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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