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Invitrogen
TET2 Polyclonal Antibody
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FIGURE: 1 / 6
TET2 Antibody (PA5-78514) in ICC/IF
Product Details
PA5-78514
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
Storage buffer
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RRID
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2, DDDDK-human TET2-transfected 293T
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2's role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLJ20032; Methylcytosine dioxygenase TET2; MGC125715; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Tet 2; tet oncogene family member 2
Gene Aliases: KIAA1546; MDS; Nbla00191; TET2
UniProt ID: (Human) Q6N021
Entrez Gene ID: (Human) 54790
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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