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Proteintech
TCTN2 Polyclonal Antibody
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Product Details
17053-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: VIYEEATDL DKFITNTETP LNNGSTPRIV NVEEHYIFKW NNNTISEINV KIFRAEINAH QKGIMTQRFV VKFLSYNSGN EEELSGNPGY QLGKPVRALN INRMNNVTTL HLWQSAGRGL CTSATFKPIL FGENVLSGCL LEVGINENCT QLRENAVERL DSLIQATHVA MRGNSDYADL SDGWLEIIRV DAPDPGADPL ASSVNGMCLD IPAHLSIRIL ISDAGAVEGI TQQEILGVET RFSSVNWQYQ CGLTCEHKAD LLPISASVQF IKIPAQLPHP LTRFQINYTE YDCNRNEVCW PQLLYPWTQY YQGELHSQCV AKGLLLLLFL TLALFLSNPW TRICKAYS (351-697 aa encoded by BC009112)
Target Information
TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: tectonic 2; Tectonic-2
Gene Aliases: 4432405B04Rik; C12orf38; JBTS24; MKS8; TCTN2; TECT2
UniProt ID: (Human) Q96GX1, (Rat) Q3B7D3, (Mouse) Q2MV57
Entrez Gene ID: (Human) 79867, (Rat) 689779, (Mouse) 67978
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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