Invitrogen

TACR1 Recombinant Rabbit Monoclonal Antibody (9T1W2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
TACR1 Recombinant Rabbit Monoclonal Antibody (9T1W2)

Product Details

MA5-35555

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9T1W2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 300-407 of human Neurokinin 1 Receptor (NK1R) (NK1R) (P25103)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849455

Product Specific Information

Immunogen sequence: YNPIIYCCLN DRFRLGFKHA FRCCPFISAG DYEGLEMKST RYLQTQGSVY KVSRLETTIS TVVGAHEEEP EDGPKATPSS LDLTSNCSSR SDSKTMTESF SFSSNVLS

Target Information

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1

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UniProt ID: (Human) P25103, (Mouse) P30548, (Rat) P14600

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Entrez Gene ID: (Human) 6869, (Mouse) 21336, (Rat) 24807

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Function(s)
tachykinin receptor activity protein binding substance P receptor activity signal transducer activity G-protein coupled receptor activity
Process(es)
aggressive behavior positive regulation of leukocyte migration angiotensin-mediated drinking behavior signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission learning or memory long-term memory regulation of blood pressure associative learning response to heat response to hormone response to ozone positive regulation of epithelial cell migration response to auditory stimulus response to organic cyclic compound regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to nicotine operant conditioning positive regulation of renal sodium excretion sperm ejaculation eating behavior positive regulation of vascular permeability response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of saliva secretion positive regulation of hormone secretion response to pain behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction acute inflammatory response response to estradiol response to progesterone response to morphine response to electrical stimulus inflammatory response cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway detection of abiotic stimulus positive regulation of smooth muscle contraction
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