Abnova

TACR1 Monoclonal Antibody (1F7)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
TACR1 Monoclonal Antibody (1F7)

Product Details

H00006869-M10

Applications
Tested Dilution
Publications

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1F7

Immunogen

TACR1 (NP_001049, 140 a.a. approximately 243 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Sandwich ELISA (Recombinant protein).

Immunogen sequence: PRLSATATKV VICVIWVLAL LLAFPQGYYS TTETMPSRVV CMIEWPEHPN KIYEKVYHIC VTVLIYFLPL LVIGYAYTVV GITLWASEIP GDSSDRYHEQ VSAK

Target Information

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: NK-1 receptor; NK-1R; SPR; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1

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UniProt ID: (Human) P25103

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Entrez Gene ID: (Human) 6869

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Function(s)
tachykinin receptor activity protein binding substance P receptor activity
Process(es)
aggressive behavior acute inflammatory response positive regulation of leukocyte migration angiotensin-mediated drinking behavior inflammatory response cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway chemical synaptic transmission long-term memory associative learning response to heat detection of abiotic stimulus response to ozone positive regulation of epithelial cell migration response to auditory stimulus regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to estradiol response to progesterone response to nicotine operant conditioning positive regulation of renal sodium excretion sperm ejaculation eating behavior positive regulation of vascular permeability response to morphine response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of saliva secretion positive regulation of hormone secretion behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly response to electrical stimulus smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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