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Invitrogen
Sortilin Recombinant Rabbit Monoclonal Antibody (23GB4170)
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FIGURE: 1 / 2
Sortilin Antibody (MA5-53702) in WB
Product Details
MA5-53702
Species Reactivity
Host/Isotype
Expression System
Class
Type
Clone
Immunogen
Conjugate
Form
Purification
Storage buffer
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RRID
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 100 kDa NT receptor; Glycoprotein 95; Gp95; Neurotensin receptor 3; NT3; Sortilin
Gene Aliases: Gp95; LDLCQ6; NT3; NTR3; SORT1
UniProt ID: (Human) Q99523
Entrez Gene ID: (Human) 6272
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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