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Invitrogen
Sortilin Recombinant Rabbit Monoclonal Antibody (10H29L22)
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FIGURE: 1 / 3
Sortilin Antibody (703207) in WB
Product Details
703207
Species Reactivity
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Product Specific Information
This antibody is predicted to react with Monkey, Cat, Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin
Gene Aliases: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Nts3; Ntsr3; SORT1
UniProt ID: (Human) Q99523, (Mouse) Q6PHU5, (Rat) O54861
Entrez Gene ID: (Human) 6272, (Mouse) 20661, (Rat) 83576
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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