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NeoBiotechnologies
Sarcomeric Actinin Alpha 2/ACTN2 Recombinant Rabbit Monoclonal Antibody (ACTN2/8184R)
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Product Details
88-RBM14-P1
Species Reactivity
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Immunogen
Conjugate
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Product Specific Information
Positive Control:Human skeletal or cardiac muscle.
Cellular Location: Cytoplasm.
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: actinin, alpha 2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; F-actin cross-linking protein
Gene Aliases: ACTN2; CMD1AA; CMH23
UniProt ID: (Human) P35609
Entrez Gene ID: (Human) 88
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