Proteintech

STK3 Monoclonal Antibody (1C11A4)

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Datasheet
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Datasheet
Protocols
Questions & Answers
STK3 Monoclonal Antibody (1C11A4)

Product Details

66637-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1C11A4

Immunogen

STK3 Fusion Protein Ag2741 (1-306 aa encoded by BC010640)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEQPPAPKS KLKKLSEDSL TKQPEEVFDV LEKLGEGSYG SVFKAIHKES GQVVAIKQVP VESDLQEIIK EISIMQQCDS PYVVKYYGSY FKNTDLWIVM EYCGAGSVSD IIRLRNKTLI EDEIATILKS TLKGLEYLHF MRKIHRDIKA GNILLNTEGH AKLADFGVAG QLTDTMAKRN TVIGTPFWMA PEVIQEIGYN CVADIWSLGI TSIEMAEGKP PYADIHPMRA IFMIPTNPPP TFRKPELWSD DFTDFVKKCL VKNPEQRATA TQLLQHPFIK NAKPVSILRD LITEAMEIKA KRHEEQQ (1-306 aa encoded by BC010640)

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: KB-1458E12.1; Mammalian STE20-like protein kinase 2; MST-2; protein kinase homolog; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase Krs-1; STE20-like kinase MST2

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Gene Aliases: 0610042I06Rik; KRS1; Mess1; MST; MST2; Mst3; Ste20; STK3

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UniProt ID: (Human) Q13188, (Rat) O54748, (Mouse) Q9JI10

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Entrez Gene ID: (Human) 6788, (Rat) 65189, (Mouse) 56274

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein serine/threonine kinase activator activity protein dimerization activity metal ion binding nucleotide binding MAP kinase kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
neural tube formation endocardium development protein phosphorylation apoptotic process central nervous system development negative regulation of cell proliferation signal transduction by protein phosphorylation positive regulation of protein binding hippo signaling intracellular signal transduction positive regulation of apoptotic process positive regulation of fat cell differentiation positive regulation of JNK cascade negative regulation of organ growth protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein kinase B signaling primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development negative regulation of canonical Wnt signaling pathway hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors signal transduction positive regulation of protein serine/threonine kinase activity MAPK cascade activation of MAPKK activity regulation of mitotic cell cycle phosphorylation stress-activated protein kinase signaling cascade
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