Abnova

STAR Monoclonal Antibody (5F9)

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Datasheet
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Datasheet
Protocols
Questions & Answers
STAR Monoclonal Antibody (5F9)

Product Details

H00006770-M01

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

0.03 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

5F9

Immunogen

STAR (AAH10550, 81 a.a. approximately 180 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: EAMQKALGIL SNQEGWKKES QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTFITHEL AAEAAGNLVG

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholesterol trafficker; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP

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Gene Aliases: STAR; STARD1

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UniProt ID: (Human) P49675

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Entrez Gene ID: (Human) 6770

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Function(s)
protein binding cholesterol binding cholesterol transporter activity
Process(es)
steroid biosynthetic process bile acid biosynthetic process C21-steroid hormone biosynthetic process progesterone biosynthetic process estrogen biosynthetic process brain development response to nutrient cholesterol metabolic process glucocorticoid metabolic process male gonad development response to herbicide response to ionizing radiation response to lead ion positive regulation of gene expression response to activity diterpenoid metabolic process insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process intracellular cholesterol transport cellular response to insulin stimulus response to nicotine cellular response to interferon-alpha response to drug response to hydrogen peroxide circadian sleep/wake cycle, REM sleep negative regulation of neuron apoptotic process response to estrogen response to leptin cellular response to fibroblast growth factor stimulus response to ethanol regulation of neuronal synaptic plasticity positive regulation of neurogenesis response to corticosterone response to fungicide testosterone biosynthetic process positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus
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