Proteintech

STAR Monoclonal Antibody (1G6E6)

1 Reference
View all (31) STAR antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

67130-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:20,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:800
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G6E6

Immunogen

STAR Fusion Protein Ag28698

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cholesterol trafficker; lipid transporter; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP

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Gene Aliases: STAR; STARD1

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UniProt ID: (Human) P49675, (Rat) P97826

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Entrez Gene ID: (Human) 6770, (Pig) 396597, (Rat) 25557

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Function(s)
protein binding cholesterol binding cholesterol transporter activity
Process(es)
organic acid metabolic process steroid biosynthetic process bile acid biosynthetic process progesterone biosynthetic process estrogen biosynthetic process brain development response to nutrient circadian rhythm cholesterol metabolic process glucocorticoid metabolic process male gonad development response to herbicide response to toxic substance response to organic substance response to ionizing radiation response to lead ion positive regulation of gene expression response to organic cyclic compound response to activity diterpenoid metabolic process response to insecticide insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process response to nutrient levels intracellular cholesterol transport cellular response to insulin stimulus response to gonadotropin response to nicotine cellular response to interferon-alpha response to drug response to hydrogen peroxide circadian sleep/wake cycle, REM sleep response to peptide hormone negative regulation of neuron apoptotic process response to estrogen cellular lipid metabolic process response to leptin cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic regulation of neuronal synaptic plasticity response to steroid hormone positive regulation of neurogenesis regulation of steroid biosynthetic process response to corticosterone response to fungicide testosterone biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to metal ion cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus C21-steroid hormone biosynthetic process positive regulation of bile acid biosynthetic process
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