Invitrogen

STAR Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
STAR Polyclonal Antibody

Product Details

PA5-106859

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Avian, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human STAR(Accession P49675), corresponding to amino acid residues Q158-N208.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854523

Product Specific Information

Antibody detects endogenous levels of total STAR.

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholesterol trafficker; Luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP

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Gene Aliases: AV363654; D8Ertd419e; STAR; STARD1

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UniProt ID: (Human) P49675, (Mouse) P51557, (Rat) P97826

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Entrez Gene ID: (Human) 6770, (Mouse) 20845, (Rat) 25557

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Function(s)
protein binding cholesterol binding cholesterol transporter activity lipid binding
Process(es)
steroid biosynthetic process bile acid biosynthetic process estrogen biosynthetic process transport lipid transport glucocorticoid metabolic process positive regulation of gene expression cellular response to interferon-alpha negative regulation of neuron apoptotic process cellular lipid metabolic process regulation of neuronal synaptic plasticity positive regulation of neurogenesis regulation of steroid biosynthetic process organic acid metabolic process progesterone biosynthetic process brain development response to nutrient circadian rhythm cholesterol metabolic process male gonad development response to herbicide response to toxic substance response to organic substance response to ionizing radiation response to lead ion response to organic cyclic compound response to activity diterpenoid metabolic process response to insecticide insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process response to nutrient levels intracellular cholesterol transport cellular response to insulin stimulus response to gonadotropin response to nicotine response to drug response to hydrogen peroxide circadian sleep/wake cycle, REM sleep response to peptide hormone response to estrogen response to leptin cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic response to steroid hormone response to corticosterone response to fungicide testosterone biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to metal ion cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus C21-steroid hormone biosynthetic process positive regulation of bile acid biosynthetic process
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