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OriGene

ST2 (IL1RL1) Monoclonal Antibody (OTI5E10), TrueMAB™

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite ST2 (IL1RL1) Monoclonal Antibody (OTI5E10), TrueMAB™

ST2 (IL1RL1) Monoclonal Antibody (OTI5E10), TrueMAB™

Product Details

CF810080

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI5E10

Immunogen

Full length human recombinant protein of human ST2 (NP_057316) produced in HEK293E
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

See Label

Purification

Protein A/G

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL-1RL1; IL-33R; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin-1 receptor-like 1; Interleukin1 receptor like 1; Protein ST2; sIL 33R; soluble IL 33 Receptor; soluble IL 33R

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Gene Aliases: DER4; FIT-1; IL1RL1; IL33R; ST2; ST2L; ST2V; T1

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UniProt ID: (Human) Q01638

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Entrez Gene ID: (Human) 9173

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Function(s)
interleukin-33 binding interleukin-33 receptor activity cytokine receptor activity interleukin-1 receptor activity receptor signaling protein activity protein binding
Process(es)
negative regulation of T-helper 1 type immune response immune response signal transduction negative regulation of cell proliferation negative regulation of interferon-gamma production positive regulation of interleukin-5 production interleukin-33-mediated signaling pathway positive regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of inflammatory response positive regulation of chemokine secretion cellular response to peptide
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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