Invitrogen

SR-BI Monoclonal Antibody (2B2A11)

View all (26) SR-BI antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-48413

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2B2A11

Immunogen

Purified recombinant fragment of human SCARB1 (AA: Extra(33-232)) expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093480

Target Information

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SRB1

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Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI

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UniProt ID: (Human) Q8WTV0, (Mouse) Q61009

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Entrez Gene ID: (Human) 949, (Mouse) 20778

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Function(s)
lipopolysaccharide binding virus receptor activity phosphatidylserine binding lipopolysaccharide receptor activity transporter activity protein binding 1-phosphatidylinositol binding high-density lipoprotein particle binding low-density lipoprotein particle binding apolipoprotein binding apolipoprotein A-I binding protein homodimerization activity high-density lipoprotein particle receptor activity
Process(es)
endothelial cell proliferation pattern recognition receptor signaling pathway androgen biosynthetic process cholesterol catabolic process lipid transport receptor-mediated endocytosis phagocytosis, recognition cell adhesion positive regulation of triglyceride biosynthetic process positive regulation of cholesterol storage regulation of phosphatidylcholine catabolic process phospholipid transport lipopolysaccharide transport cholesterol transport lipopolysaccharide-mediated signaling pathway detection of lipopolysaccharide cholesterol efflux high-density lipoprotein particle remodeling low-density lipoprotein particle clearance high-density lipoprotein particle clearance vitamin transmembrane transport cholesterol homeostasis blood vessel endothelial cell migration recognition of apoptotic cell reverse cholesterol transport adhesion of symbiont to host regulation of phagocytosis positive regulation of nitric-oxide synthase activity triglyceride homeostasis cholesterol import positive regulation of endothelial cell migration wound healing lipoprotein metabolic process viral entry into host cell intestinal absorption
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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