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Invitrogen
SPACA1 Polyclonal Antibody
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Product Details
PA5-60314
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Immunogen sequence: LRQDQQSIIL VNDSAILEVR KESHPLAFEC DTLDNNEIVA TIKFTVYTSS ELQMRRSSLP A
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 69%.
Target Information
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Sperm acrosomal membrane-associated protein 32; Sperm acrosome membrane-associated protein 1
Gene Aliases: SAMP32; SPACA1
UniProt ID: (Human) Q9HBV2
Entrez Gene ID: (Human) 81833
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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