Invitrogen

SOX4 Recombinant Rabbit Monoclonal Antibody (4A1E8)

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Datasheet
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Datasheet
Protocols
Questions & Answers
SOX4 Recombinant Rabbit Monoclonal Antibody (4A1E8)

Product Details

MA5-55338

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:20,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4A1E8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX4.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667579

Product Specific Information

Immunogen Sequence: AAGRSPADHR GYASLRAASP APSSAPSHAS SSASSHSSSS SSSGSSSSDD EFEDDLLDLN PSSNFESMSL GSFSSSSALD RDLDFNFEPG SGSHFEFPDY C

Target Information

SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ecotropic viral integration site 16; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box containing gene 4; SRY-related HMG-box gene 4; Transcription factor SOX-4

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Gene Aliases: AA682046; EVI16; Sox-4; SOX4

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UniProt ID: (Human) Q06945, (Mouse) Q06831

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Entrez Gene ID: (Human) 6659, (Rat) 364712, (Mouse) 20677

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Function(s)
transcription regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding nucleic acid binding transcription factor activity transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding protein binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding
Process(es)
skeletal system development response to hypoxia neural tube formation pro-B cell differentiation mitral valve morphogenesis cardiac ventricle formation cardiac right ventricle morphogenesis atrial septum primum morphogenesis noradrenergic neuron differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development positive regulation of cell proliferation negative regulation of cell proliferation glial cell proliferation spinal cord development spinal cord motor neuron differentiation glial cell development positive regulation of Wnt signaling pathway T cell differentiation endocrine pancreas development negative regulation of protein ubiquitination regulation of protein stability positive regulation of insulin secretion somatic stem cell population maintenance ascending aorta morphogenesis glucose homeostasis DNA damage response, detection of DNA damage positive regulation of apoptotic process positive regulation of translation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of protein export from nucleus sympathetic nervous system development protein stabilization canonical Wnt signaling pathway limb bud formation ventricular septum morphogenesis negative regulation of cell death neuroepithelial cell differentiation kidney morphogenesis cellular response to glucose stimulus positive regulation of canonical Wnt signaling pathway positive regulation of N-terminal peptidyl-lysine acetylation transcription, DNA-templated
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