Invitrogen

SMAD6 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
SMAD6 Polyclonal Antibody

Product Details

PA5-87457

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_0055763)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.33 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804165

Product Specific Information

Immunogen sequence: PTVCCNPYHF SRLCGPESPP PPYSRLSPRD EYKPLDLSDS TLSYTETEAT NSLITAPGEF SDASMSPDAT KPSHWCSVAY WEHRTRVGRL YAVYDQAVSI FYDLPQGSGF CLGQLNLEQR SESVRRTRSK IGFGILLSKE PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL QHAPEPDAAD GPYDPNSVRI SFAKGWGPCY SRQFITSCPC WLEILLNNPR; Positive Samples: 22Rv1, Mouse heart, Rat brain; Cellular Location: Nucleus

Target Information

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6

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Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6

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UniProt ID: (Human) O43541, (Mouse) O35182

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Entrez Gene ID: (Human) 4091, (Mouse) 17130, (Rat) 367100

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding transcription regulatory region DNA binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding type I activin receptor binding DNA binding molecular_function
Process(es)
ureteric bud development outflow tract septum morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development transcription, DNA-templated immune response transforming growth factor beta receptor signaling pathway zygotic specification of dorsal/ventral axis negative regulation of cell proliferation negative regulation of SMAD protein complex assembly negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway cell-substrate adhesion response to laminar fluid shear stress aorta development negative regulation of apoptotic process response to estrogen fat cell differentiation negative regulation of pathway-restricted SMAD protein phosphorylation coronary vasculature development regulation of transcription, DNA-templated intracellular signal transduction positive regulation of vasoconstriction negative regulation of vasodilation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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