Invitrogen

SMAD6 Polyclonal Antibody

View all (17) SMAD6 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
SMAD6 Polyclonal Antibody

Product Details

PA1-29829

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL
-

Immunocytochemistry (ICC/IF)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Sheep, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptides found between amino acids 30-150 and 300-400 of human SMAD6.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2193469

Product Specific Information

PA1-29829 detects SMAD6 from mouse, human samples.

Target Information

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6

View more View less

Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6

View more View less

UniProt ID: (Human) O43541, (Mouse) O35182

View more View less

Entrez Gene ID: (Human) 4091, (Sheep) 101103068, (Mouse) 17130, (Rat) 367100

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding transcription regulatory region DNA binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding type I activin receptor binding DNA binding molecular_function
Process(es)
ureteric bud development outflow tract septum morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development transcription, DNA-templated immune response transforming growth factor beta receptor signaling pathway zygotic specification of dorsal/ventral axis negative regulation of cell proliferation negative regulation of SMAD protein complex assembly negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway cell-substrate adhesion response to laminar fluid shear stress aorta development negative regulation of apoptotic process response to estrogen fat cell differentiation negative regulation of pathway-restricted SMAD protein phosphorylation coronary vasculature development regulation of transcription, DNA-templated intracellular signal transduction positive regulation of vasoconstriction negative regulation of vasodilation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support