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Invitrogen
SLC4A4 Polyclonal Antibody
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Product Details
PA5-57344
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
Shipping conditions
RRID
Product Specific Information
Immunogen sequence: KKKGSLDSDN DDSDCPYSEK VPSIKIPMDI MEQQPFLSDS KPSDRERSPT FLERHTS
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 93%.
Target Information
Slc4a4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Slc4a4 is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. Moreover, Slc4a4 may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. Mutations in the Slc4a4 gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for the Slc4a4 gene. Diseases associated with SLC4A4 include Renal Tubular Acidosis, Proximal, With Ocular Abnormalities and Proximal Renal Tubular Acidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Electrogenic sodium bicarbonate cotransporter 1; HNBC 1; kNBC 1; kNBC1; Na(+)/HCO3(-) cotransporter; NBC 1; NBC 2; NBCE 1; OTTHUMP00000160355; OTTHUMP00000218884; OTTHUMP00000218885; Sodium bicarbonate cotransporter; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (sodium bicarbonate cotransporter), member 4; Solute carrier family 4 member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Gene Aliases: hhNMC; HNBC1; KNBC; kNBC1; NBC; NBC1; NBC2; NBCE1; NBCe1-A; pNBC; SLC4A4; SLC4A5
UniProt ID: (Human) Q9Y6R1
Entrez Gene ID: (Human) 8671
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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