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Invitrogen
SIK3 Polyclonal Antibody
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FIGURE: 1 / 3
SIK3 Antibody (PA5-115813) in ICC/IF
Product Details
PA5-115813
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Antibody detects endogenous levels of total QSK.
Target Information
SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA). SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Salt-inducible kinase 3; Serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK-3
Gene Aliases: 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; KIAA0999; L19; mKIAA0999; QSK; SIK-3; SIK3
UniProt ID: (Human) Q9Y2K2, (Mouse) Q6P4S6
Entrez Gene ID: (Human) 23387, (Mouse) 70661, (Rat) 684112
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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