Invitrogen

SFRP2 Polyclonal Antibody

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View all (18) SFRP2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
SFRP2 Polyclonal Antibody

Product Details

PA5-106726

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SFRP2(Accession Q96HF1), corresponding to amino acid residues V119-P169.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854394

Product Specific Information

Antibody detects endogenous levels of total SFRP2.

Target Information

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FRP 2; FRP-2; MGC128911; MGC153618; MGC53344; Protein SDF5; SARP 1; SARP-1; SDF 5; secreted apoptosis related protein 1; Secreted apoptosis-related protein 1; Secreted frizzled-related protein 2; secreted frizzled-related sequence protein 2; secreted frizzled-related sequence protein 5; sFRP 2; sFRP-2; Sfrp2 protein; stromal cell derived factor 5; testicular tissue protein Li 170

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Gene Aliases: AI851596; FKSG12; FRP-2; FRP2; SARP1; SDF-5; Sdf5; SFRP2; UNQ361/PRO697

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UniProt ID: (Human) Q96HF1, (Mouse) P97299

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Entrez Gene ID: (Human) 6423, (Rat) 310552, (Mouse) 20319

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Function(s)
fibronectin binding G-protein coupled receptor activity integrin binding Wnt-protein binding Wnt-activated receptor activity receptor agonist activity endopeptidase activator activity molecular_function enzyme activator activity protein binding
Process(es)
patterning of blood vessels somitogenesis neural tube closure chondrocyte development outflow tract morphogenesis cardiac left ventricle morphogenesis apoptotic process signal transduction response to nutrient positive regulation of cell proliferation negative regulation of cell proliferation male gonad development anterior/posterior pattern specification negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process negative regulation of epithelial to mesenchymal transition positive regulation of endopeptidase activity neural tube development regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway collagen fibril organization positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway cellular response to extracellular stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of catenin import into nucleus non-canonical Wnt signaling pathway post-anal tail morphogenesis regulation of cell proliferation response to drug negative regulation of mesodermal cell fate specification embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of JUN kinase activity positive regulation of fat cell differentiation positive regulation of osteoblast differentiation positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter development of primary male sexual characteristics digestive tract morphogenesis negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation cartilage development convergent extension involved in axis elongation bone morphogenesis sclerotome development negative regulation of dermatome development hematopoietic stem cell proliferation cellular response to X-ray negative regulation of canonical Wnt signaling pathway regulation of establishment of planar polarity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of stem cell division negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of receptor activity G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell adhesion mediated by integrin negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of dopaminergic neuron differentiation midbrain morphogenesis multicellular organism development Wnt signaling pathway cell differentiation canonical Wnt signaling pathway
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