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Invitrogen
SCF Polyclonal Antibody
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FIGURE: 1 / 2
SCF Antibody (PA5-47290) in ICC/IF
Product Details
PA5-47290
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
In sandwich ELISAs, less than 20% cross-reactivity with recombinant feline SCF is observed, less than 8% cross-reactivity with recombinant human SCF is observed, and less than 0.5% cross-reactivity with recombinant mouse SCF is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: c-Kit ligand; DKFZp686F2250; H-SCF; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; Stem cell factor; stem cell factor, CSF
Gene Aliases: 710-712; CSF; KITLG; MGF
UniProt ID: (Dog) Q06220
Entrez Gene ID: (Dog) 403507
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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