Invitrogen

SAP97 Polyclonal Antibody

View all (15) SAP97 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
SAP97 Polyclonal Antibody

Product Details

PA5-121207

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human DLG1 (NP_004078.2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914779

Product Specific Information

Positive test controls include: U-87MG, LO2, HeLa, Jurkat. The target is usually found in the following locations: Basolateral cell membrane, Cell junction, Cell membrane, Endoplasmic reticulum membrane, Membrane, Peripheral membrane protein, postsynaptic cell membrane, postsynaptic density, sarcolemma, synapse.

Immunogen sequence: MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG FVSHSHISPI KPTEAVLPSP PTVPVIPVLP VPAENTVILP

Target Information

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; Disks large homolog 1; DKFZp761P0818; DKFZp781B0426; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97

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Gene Aliases: B130052P05Rik; dJ1061C18.1.1; DLG1; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

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UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q811D0

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Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

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Function(s)
guanylate kinase activity phosphoprotein phosphatase activity protein binding protein C-terminus binding cytoskeletal protein binding ligand-gated ion channel activity potassium channel regulator activity protein kinase binding phosphatase binding mitogen-activated protein kinase kinase binding protein complex scaffold ionotropic glutamate receptor binding ion channel binding L27 domain binding cadherin binding involved in cell-cell adhesion PDZ domain binding kinase binding
Process(es)
ureteric bud development branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye T cell cytokine production actin filament organization cell adhesion chemical synaptic transmission nervous system development protein localization positive regulation of cell proliferation single organismal cell-cell adhesion peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization membrane raft organization regulation of myelination activation of protein kinase activity regulation of protein localization T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering positive regulation of potassium ion transport establishment or maintenance of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle nucleotide phosphorylation reproductive structure development embryonic skeletal system morphogenesis tissue morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation negative regulation of protein kinase B signaling hard palate development bicellular tight junction assembly protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane receptor localization to synapse positive regulation of multicellular organism growth positive regulation of developmental growth negative regulation of transcription from RNA polymerase II promoter protein dephosphorylation mitotic cell cycle checkpoint establishment or maintenance of cell polarity regulation of cell shape viral process astral microtubule organization ion transmembrane transport cellular protein complex localization cortical microtubule organization GMP metabolic process GDP metabolic process establishment of centrosome localization negative regulation of ERK1 and ERK2 cascade regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport negative regulation of p38MAPK cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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