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Invitrogen
S100A12 Recombinant Rabbit Monoclonal Antibody (4A9D7)
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FIGURE: 1 / 1
S100A12 Antibody (MA5-55550) in WB
Product Details
MA5-55550
Species Reactivity
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Product Specific Information
Immunogen Sequence: MTKLEEHLEG IVNIFHQYSV RKGHFDTLSK GELKQLLTKE LANTIKNIKD KAVIDEIFQG LDANQDEQVD FQEFISLVAI ALKAAHYHTH KE
Target Information
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CAAF1; CAGC; calcitermin; Calcium-binding protein in amniotic fluid 1; calgranulin C; Calgranulin-C; CGRP; EN RAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; Migration inhibitory factor-related protein 6; MRP-6; Neutrophil S100 protein; Protein S100 A12; Protein S100-A12; S100 calcium-binding protein A12; S100 calcium-binding protein A12 (calgranulin C)
Gene Aliases: CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6; S100A12
UniProt ID: (Human) P80511
Entrez Gene ID: (Human) 6283
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