Invitrogen

RUNX1 Polyclonal Antibody

Advanced Verification
2 References
View all (44) RUNX1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
RUNX1 Polyclonal Antibody

Product Details

PA5-19638

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/ml
-

Immunocytochemistry (ICC/IF)

5 µg/ml
-

Immunoprecipitation (IP)

-
View 1 publication 1 publication

CUT&RUN (C&R)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 400 to the C-terminus of Human RUNX1 / AML1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980230

Product Specific Information

For Western Blot, this antibody has non-specific bands at 47 kDa and 75 kDa.

This antibody is predicted to react with rat and chicken based on sequence homology.

Target Information

RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; AML-1; aml1 oncogene; AML1-EVI-1 fusion protein; CBF-alpha 2; CBF-alpha-2; core binding factor alpha 2; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 2; Oncogene AML-1; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; Runt-related transcription factor 1; RUNX1/ZNF687 fusion; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; transcription factor

View more View less

Gene Aliases: AML1; AML1-EVI-1; AMLCR1; CBF-alpha-2; CBF2alpha; CBFA2; EVI-1; Pebp2a2; PEBP2aB; PEBP2alpha; Pebpa2b; RUNX1

View more View less

UniProt ID: (Human) Q01196

View more View less

Entrez Gene ID: (Human) 861, (Mouse) 12394

View more View less

Function(s)
regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding ATP binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding transcription factor binding protein homodimerization activity protein heterodimerization activity repressing transcription factor binding
Process(es)
ossification chondrocyte differentiation transcription from RNA polymerase II promoter hemopoiesis positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development hematopoietic stem cell proliferation skeletal system development in utero embryonic development liver development myeloid progenitor cell differentiation regulation of T cell anergy transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter central nervous system development negative regulation of cell proliferation regulation of signal transduction myeloid cell differentiation neuron differentiation negative regulation of granulocyte differentiation hair follicle morphogenesis response to retinoic acid positive regulation of interferon-gamma production embryonic hemopoiesis negative regulation of transcription, DNA-templated behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support