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Invitrogen
RPSA Monoclonal Antibody (RP-01), Alexa Fluor™ 488
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RPSA Antibody (MA5-44138) in Flow
Product Details
MA5-44138
Species Reactivity
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Product Specific Information
This antibody recognizes ribosomal protein SA (RPSA), which is important for formation and stability of 40S ribosomal subunit, and is overexpressed in many carcinomas.
Target Information
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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References (0)
Bioinformatics
Protein Aliases: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37-kd LR; 37/67 kDa laminin receptor; 37kD Laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67-kd LR; 67kD laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA, 67 kDA); Laminin-binding protein precursor p40; LamR; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; P40-3, functional; P40-8, functional; Protein C10; ribosomal protein SA pseudogene; rssa; Small ribosomal subunit protein uS2
Gene Aliases: 37LRP; 67kDa; 67LR; AL022858; BOS_20678; DMRT1; ICAS; LAMBR; LamR; LAMR1; Lamrl1; LBP; LBP/p40; LR; LRP; LRP/LR; MLR; NEM/1CHD4; P40; P40-3; P40-8; RPSA; SA; XELAEV_18023531mg
UniProt ID: (Bovine) P26452, (Human) P08865, (Chicken) P50890, (Mouse) P14206, (Xenopus) Q3ZM03
Entrez Gene ID: (Bovine) 281898, (Human) 3921, (Chicken) 395181, (Mouse) 16785, (Xenopus) 733335
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