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Abnova
ROR1 Monoclonal Antibody (1B4)
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Product Details
H00004919-M02
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
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Purification
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Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: ANCIRIGIPM ADPINKNHKC YNSTGVDYRG TVSVTKSGRQ CQPWNSQYPH THTFTALRFP ELNGGHSYCR NPGNQKEAPW CFTLDENFKS DLCDIPACGK
Target Information
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; Neurotrophic tyrosine kinase, receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; T-ROR1
Gene Aliases: dJ537F10.1; NTRKR1; ROR1
UniProt ID: (Human) Q01973
Entrez Gene ID: (Human) 4919
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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