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Abnova
ROBO3 Monoclonal Antibody (2H1)
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Product Details
H00064221-M02
Species Reactivity
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Conjugate
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Product Specific Information
Sequence of this protein is as follows: MTPPLQGPRA RFRKKPKALP YRRENSPGDL PPPPLPPPEE EASWALELRA AGSMSSLERE RSGERKAVQA VPLAAQRVLH PDEEAWLPYS RPSFLSRGQG TSTCSTAGSN SSRGSSSSRG SRGPGRSRSQ SRSQSQRPGQ KRREEPR
Target Information
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLJ21044; retinoblastoma inhibiting gene 1; Roundabout homolog 3; roundabout, axon guidance receptor, homolog 3; Roundabout-like protein 3
Gene Aliases: HGPPS; HGPS; RBIG1; RIG1; ROBO3
UniProt ID: (Human) Q96MS0
Entrez Gene ID: (Human) 64221
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