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Invitrogen
RNASE3 Monoclonal Antibody (5G4)
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FIGURE: 1 / 6
RNASE3 Antibody (MA5-34931) in ICC/IF
Product Details
MA5-34931
Species Reactivity
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Product Specific Information
Positive Control: U937, Hela, SHG-44, human spleen tissue, human kidney tissue.
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cytotoxic ribonuclease; ECP; Eosinophil cationic protein; Ribonuclease 3; ribonuclease, RNase A family, 3; RNase 3
Gene Aliases: ECP; RAF1; RNASE3; RNS3
UniProt ID: (Human) P12724
Entrez Gene ID: (Human) 6037
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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