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Invitrogen
REG3G Polyclonal Antibody
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Product Details
PA5-76092
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
Storage buffer
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RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
REG3G, also known as regenerating islet-derived 3 gamma, is a gene encoding an antimicrobial peptide crucial for maintaining intestinal homeostasis and regulating host-microbiome interactions. The protein produced by REG3G belongs to the C-type lectin family and is primarily expressed in the gut, where it plays a significant role in defending against bacterial infections. REG3G helps maintain gut barrier function and immune responses, acting in collaboration with interleukin 22 (IL-22), which regulates its expression. This gene is downregulated during chronic ethanol exposure, suggesting an influence on susceptibility to alcoholic liver disease. REG3G is also involved in glucose metabolism, with evidence showing that its administration improves glucose tolerance, potentially through actions mediated by its receptor, Extl3. Furthermore, REG3G has been identified as a nociceptor-enriched hormone, which protects against endotoxic shock by modulating both local and systemic immunity. This diverse functionality underscores the gene's importance in immune modulation, gut physiology, and metabolic processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: generating islet-derived, mouse homolog 3 gamma; Pancreatitis-associated protein 1B; Pancreatitis-associated protein 3; Pancreatitis-associated protein IB; PAP IB; PAP-1B; REG III; Reg III-gamma; REG-3-gamma; REG-3gamma; REG3gamma; regenerating gene III; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3 gamma; Regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein III-gamma; RegIII (gamma)
Gene Aliases: AI449515; LPPM429; PAP IB; PAP-1B; PAP1B; Pap3; PAPIB; PAPIII; REG III; REG-III; REG3G; UNQ429; UNQ429/PRO162
UniProt ID: (Human) Q6UW15, (Mouse) O09049, (Rat) P42854
Entrez Gene ID: (Human) 130120, (Mouse) 19695, (Rat) 24620
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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