Invitrogen

RARB Recombinant Rabbit Monoclonal Antibody (6D5V4)

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Datasheet
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Datasheet
Protocols
Questions & Answers
RARB Recombinant Rabbit Monoclonal Antibody (6D5V4)

Product Details

MA5-35529

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6D5V4

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 350-455 of human RARβ (NP_0009562)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.15 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849429

Product Specific Information

Immunogen sequence: KLQEPLLEAL KIYIRKRRPS KPHMFPKILM KITDLRSISA KGAERVITLK MEIPGSMPPL IQEMLENSEG HEPLTPSSSG NTAEHSPSIS PSSVENSGVS QSPLVQ

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide

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Gene Aliases: A830025K23; HAP; MCOPS12; NR1B2; RARB; RARbeta1; RRB2

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UniProt ID: (Human) P10826, (Mouse) P22605

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Entrez Gene ID: (Human) 5915, (Mouse) 218772

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding steroid hormone receptor activity retinoic acid receptor activity drug binding zinc ion binding protein complex binding retinoid X receptor binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development glandular epithelial cell development outflow tract septum morphogenesis retinal pigment epithelium development growth plate cartilage development transcription initiation from RNA polymerase II promoter signal transduction positive regulation of cell proliferation negative regulation of cell proliferation striatum development regulation of myelination negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process steroid hormone mediated signaling pathway positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway embryonic digestive tract development ventricular cardiac muscle cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter neurogenesis positive regulation of programmed cell death retina development in camera-type eye bone development negative regulation of cartilage development
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