Bethyl Laboratories

RANK Polyclonal Antibody

Name: RANK Polyclonal Antibody
Brand: Bethyl Laboratories
SKU: A303-807A

View all (43) RANK (CD265) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

FIGURE: 1 / 1

RANK Antibody (A303-807A) in WB

Detection of human RANK by western blot and immunoprecipitation. Samples: Whole cell lysate from HEK293T (15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HeLa (H; 50 µg) and Jurkat (J; 50 µg) cells. Antibodies: Affinity purified rabbit anti-RANK antibody (Product # A303-807A) used for WB at 0.4 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. RANK was also immunoprecipitated by rabbit anti-RANK antibody A303-808A, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 10 seconds (A) and ... View More

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Immunogen Image RANK Polyclonal Antibody

Product Details

A303-807A

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

Immunoprecipitation (IP)

2-10 µg/mg lysate

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 450 and 500 of Human Receptor activator of NF-KB.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD265; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

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Gene Aliases: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCER

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UniProt ID: (Human) Q9Y6Q6

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Entrez Gene ID: (Human) 8792

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Function(s)

receptor activity transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity protein binding cytokine binding metal ion binding

Process(es)

ossification adaptive immune response monocyte chemotaxis inflammatory response signal transduction cell-cell signaling positive regulation of cell proliferation response to radiation osteoclast differentiation response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway response to cytokine response to tumor necrosis factor regulation of apoptotic process positive regulation of JUN kinase activity lymph node development positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity circadian temperature homeostasis mammary gland alveolus development response to interleukin-1 positive regulation of fever generation by positive regulation of prostaglandin secretion TNFSF11-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RANK Polyclonal Antibody

RANK Antibody (A303-807A) in WB

Product Details

A303-807A

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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