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Invitrogen
RANGAP1 Recombinant Rabbit Monoclonal Antibody (1E7R7)
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Product Details
MA5-35713
Species Reactivity
Host/Isotype
Expression System
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Type
Clone
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL
Target Information
Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: MGC20266; Ran GTPase-activating protein 1; RanGAP1; segregation distorter homolog; segregation distortion
Gene Aliases: C79654; Fug1; KIAA1835; mKIAA1835; RANGAP; RANGAP1; SD
UniProt ID: (Human) P46060, (Mouse) P46061
Entrez Gene ID: (Human) 5905, (Mouse) 19387, (Rat) 362965
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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