Alomone Labs, LTD

Prostaglandin E Receptor EP4 (PTGER4) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Prostaglandin E Receptor EP4 (PTGER4) Polyclonal Antibody

Product Details

APR-066-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)RKTVLSKAIEKIK, corresponding to amino acid residues 336-348 of rat prostanoid EP4 receptor, Intracellular, C-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EP1; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; Prostanoid EP4 receptor

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Gene Aliases: EP4; EP4R; Ptger; PTGER2; PTGER4; Ptgerep4

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UniProt ID: (Human) P35408, (Mouse) P32240, (Rat) P43114

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Entrez Gene ID: (Human) 5734, (Mouse) 19219, (Rat) 84023

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Function(s)
prostaglandin E receptor activity protein binding signal transducer activity G-protein coupled receptor activity prostaglandin receptor activity
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway JNK cascade intestine smooth muscle contraction positive regulation of smooth muscle cell migration regulation of ossification positive regulation of cAMP biosynthetic process response to lipopolysaccharide positive regulation of interleukin-8 production negative regulation of integrin activation positive regulation of urine volume positive regulation of renal sodium excretion T-helper cell differentiation positive regulation of bone resorption negative regulation of cytokine secretion positive regulation of cytokine secretion negative regulation of inflammatory response positive regulation of inflammatory response negative regulation of oxidoreductase activity regulation of stress fiber assembly bone development positive regulation of mucus secretion ERK1 and ERK2 cascade ductus arteriosus closure positive regulation of hyaluronan biosynthetic process positive regulation of ovarian follicle development positive regulation of antral ovarian follicle growth positive regulation of neutrophil extravasation negative regulation of eosinophil extravasation negative regulation of peroxidase activity negative regulation of peptide secretion immune response positive regulation of cytosolic calcium ion concentration female pregnancy positive regulation of cell proliferation response to mechanical stimulus positive regulation of gene expression negative regulation of hydrogen peroxide metabolic process regulation of circadian sleep/wake cycle, wakefulness response to progesterone negative regulation of circadian sleep/wake cycle, REM sleep chemokinesis response to drug positive regulation of tyrosine phosphorylation of Stat3 protein response to amino acid positive regulation of osteoblast differentiation positive regulation of cell adhesion positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of interleukin-1 alpha secretion negative regulation of nitric-oxide synthase biosynthetic process maternal process involved in parturition cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to interleukin-1 cellular response to prostaglandin E stimulus positive regulation of wound healing response to salt negative regulation of ductus arteriosus closure negative regulation of small intestine smooth muscle contraction positive regulation of calcitonin secretion positive regulation of chemokinesis positive regulation of matrix metallopeptidase secretion negative regulation of tumor necrosis factor secretion negative regulation of endothelin secretion positive regulation of substance P secretion, neurotransmission response to water-immersion restraint stress positive regulation of interleukin-10 secretion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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