Bioss

Pleiotrophin Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Pleiotrophin Polyclonal Antibody

Product Details

BS-2444R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PTN, amino acids 101-168.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory peptide; heparin affin regulatory protein; heparin binding factor; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurite promoting factor; heparin-binding neurotorphic factor; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; osteoblastic cell factor; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); PTN

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Gene Aliases: HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF; OSF-1; Osf1; PTN

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UniProt ID: (Human) P21246, (Rat) P63090, (Mouse) P63089

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Entrez Gene ID: (Human) 5764, (Rat) 24924, (Mouse) 19242

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Function(s)
protein phosphatase inhibitor activity growth factor activity heparin binding chondroitin sulfate proteoglycan binding chondroitin sulfate binding vascular endothelial growth factor binding heparan sulfate binding glycosaminoglycan binding
Process(es)
liver development transmembrane receptor protein tyrosine phosphatase signaling pathway nervous system development heart development learning positive regulation of cell proliferation regulation of cell shape positive regulation of cell-substrate adhesion positive regulation of neuron projection development response to activity negative regulation of angiogenesis spinal cord development cerebellum development thalamus development bone mineralization lung development negative regulation of cell migration response to estradiol response to progesterone cellular response to UV cellular response to platelet-derived growth factor stimulus response to drug positive regulation of apoptotic process negative regulation of catalytic activity estrous cycle endothelial cell differentiation negative regulation of membrane potential negative regulation of epithelial cell proliferation positive regulation of cell division retinal rod cell differentiation negative regulation of glial cell proliferation long-term synaptic potentiation cellular response to vitamin D cellular response to hypoxia negative regulation of mesenchymal cell proliferation response to kainic acid rod bipolar cell differentiation response to ciliary neurotrophic factor positive regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of neuromuscular junction development response to nerve growth factor positive regulation of hepatocyte proliferation ossification neuromuscular junction development skeletal muscle acetylcholine-gated channel clustering
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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