Bioss

Phospho-gp130 (Ser782) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-gp130 (Ser782) Polyclonal Antibody

Product Details

BS-10122R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human gp130 around the phosphorylation site of Ser782.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha

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Gene Aliases: 5133400A03Rik; AA389424; Ac1055; BB405851; CD130; CDW130; D13Ertd699e; GP130; IL-6RB; IL6ST

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UniProt ID: (Human) P40189, (Mouse) Q00560

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Entrez Gene ID: (Human) 3572, (Rat) 25205, (Mouse) 16195

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Function(s)
ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-11 receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding interleukin-6 receptor binding protein binding growth factor binding interleukin-11 binding interleukin-6 binding protein homodimerization activity interleukin-27 receptor activity protein heterodimerization activity cytokine receptor activity
Process(es)
glycogen metabolic process triglyceride mobilization signal transduction response to nutrient positive regulation of cell proliferation regulation of Notch signaling pathway positive regulation of smooth muscle cell migration cytokine-mediated signaling pathway response to cytokine interleukin-11-mediated signaling pathway oncostatin-M-mediated signaling pathway positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of osteoblast differentiation regulation of hormone secretion positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway negative regulation of cytosolic calcium ion concentration interleukin-6-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway positive regulation of acute inflammatory response positive regulation of adaptive immune response positive regulation of vascular endothelial growth factor production positive regulation of cardiac muscle hypertrophy viral process negative regulation of apoptotic process
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