Invitrogen

Phospho-TrkA (Tyr757) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-TrkA (Tyr757) Polyclonal Antibody

Product Details

PA5-37670

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554278

Product Specific Information

A suggested positive control for IHC is human brain tissue.

Target Information

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Trk-A; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A

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Gene Aliases: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA

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UniProt ID: (Human) P04629, (Mouse) Q3UFB7

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Entrez Gene ID: (Human) 4914, (Mouse) 18211

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Function(s)
transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding nucleotide binding protein kinase activity protein tyrosine kinase activity neurotrophin receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance learning or memory programmed cell death involved in cell development response to activity phosphorylation peptidyl-tyrosine phosphorylation sensory perception of pain cell differentiation B cell differentiation response to nutrient levels response to nicotine nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of angiogenesis protein autophosphorylation neurotrophin TRK receptor signaling pathway sympathetic nervous system development detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain cellular response to nicotine cellular response to growth factor stimulus negative regulation of neuron death cellular response to nerve growth factor stimulus activation of MAPKK activity positive regulation of protein phosphorylation microtubule-based movement aging circadian rhythm negative regulation of cell proliferation response to radiation positive regulation of neuron projection development olfactory nerve development positive regulation of GTPase activity response to ethanol positive regulation of Ras protein signal transduction ephrin receptor signaling pathway phosphatidylinositol-mediated signaling response to axon injury response to hydrostatic pressure positive regulation of ERK1 and ERK2 cascade
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