Invitrogen

Phospho-TAK1 (Thr187) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-TAK1 (Thr187) Polyclonal Antibody

Product Details

PA5-40229

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

1:100-1:300
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human Tak1 around the phosphorylation site of T187.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610279

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: M3K7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; RP1-154G14.1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1

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Gene Aliases: B430101B05; C87327; MAP3K7; MEKK7; TAK1; TGF1a

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UniProt ID: (Human) O43318, (Mouse) Q62073, (Rat) P0C8E4

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Entrez Gene ID: (Human) 6885, (Mouse) 26409, (Rat) 313121

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding scaffold protein binding nucleotide binding MAP kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
Process(es)
MAPK cascade activation of MAPK activity angiogenesis neural tube formation transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation apoptotic process transforming growth factor beta receptor signaling pathway I-kappaB phosphorylation phosphorylation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade negative regulation of necroptotic process negative regulation of ripoptosome assembly involved in necroptotic process regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of apoptotic signaling pathway activation of MAPKK activity stimulatory C-type lectin receptor signaling pathway positive regulation of T cell cytokine production MyD88-dependent toll-like receptor signaling pathway Wnt signaling pathway, calcium modulating pathway I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity JNK cascade positive regulation of interleukin-2 production Fc-epsilon receptor signaling pathway positive regulation of JUN kinase activity histone H3 acetylation T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade nucleotide-binding oligomerization domain containing signaling pathway
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