Invitrogen

Phospho-Phospholamban (Ser16) Recombinant Rabbit Monoclonal Antibody (HL1710)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-Phospholamban (Ser16) Recombinant Rabbit Monoclonal Antibody (HL1710)

Product Details

MA5-46899

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1710

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Ser16 of human phospholamban . The exact sequence is proprietary
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937971

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cardiac CMH18; cardiac phospholamban; Phospholamban; PLB

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Gene Aliases: CMD1P; CMH18; PLB; PLN

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UniProt ID: (Human) P26678, (Mouse) P61014

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Entrez Gene ID: (Human) 5350, (Mouse) 18821

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Function(s)
enzyme inhibitor activity calcium channel regulator activity protein binding ATPase inhibitor activity identical protein binding ATPase binding
Process(es)
regulation of the force of heart contraction calcium ion transport cellular calcium ion homeostasis Notch signaling pathway regulation of heart contraction response to zinc ion regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion response to testosterone negative regulation of catalytic activity negative regulation of heart contraction cardiac muscle tissue development protein homooligomerization regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in heart process regulation of the force of heart contraction by cardiac conduction regulation of calcium ion import regulation of relaxation of muscle blood circulation negative regulation of heart rate negative regulation of ATPase activity response to insulin regulation of cytosolic calcium ion concentration regulation of calcium ion transport negative regulation of calcium ion transport relaxation of cardiac muscle regulation of cardiac muscle cell membrane potential negative regulation of calcium ion import negative regulation of calcium ion transmembrane transporter activity negative regulation of calcium ion binding regulation of calcium-transporting ATPase activity negative regulation of calcium-transporting ATPase activity regulation of relaxation of cardiac muscle negative regulation of calcium ion import into sarcoplasmic reticulum regulation of cardiac conduction
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