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Invitrogen
Phospho-PDHA1 (Ser293) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-PDHA1 (Ser293) Antibody (PA5-121355) in WB
Product Details
PA5-121355
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
Positive test controls include: 293T, NIH/3T3. The target is usually found in the following locations: Mitochondrion matrix.
Immunogen sequence: GHSMS
Target Information
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: PDHE1-A type I; pyruvate dehydrogenase; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 alpha 1; Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase E1alpha subunit
Gene Aliases: PDHA; Pdha-1; PDHA1; PDHAD; PDHCE1A; PHE1A
UniProt ID: (Human) P08559, (Mouse) P35486
Entrez Gene ID: (Human) 5160, (Rat) 29554, (Mouse) 18597
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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