Bioss

Phospho-Ezrin (Thr567) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-Ezrin (Thr567) Polyclonal Antibody

Product Details

BS-3134R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human Ezrin around the phosphorylation site of Thr567.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2; villin 2 (ezrin); Villin-2

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Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2

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UniProt ID: (Human) P15311, (Mouse) P26040, (Rat) P31977

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Entrez Gene ID: (Human) 7430, (Mouse) 22350, (Rat) 54319

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Function(s)
actin binding protein binding microtubule binding protein domain specific binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding S100 protein binding poly(A) RNA binding cell adhesion molecule binding actin filament binding ATPase binding cadherin binding involved in cell-cell adhesion cytoskeletal protein binding protein complex binding structural molecule activity
Process(es)
intestinal D-glucose absorption sphingosine-1-phosphate signaling pathway regulation of cell shape positive regulation of gene expression microvillus assembly actin cytoskeleton reorganization receptor internalization regulation of microvillus length establishment or maintenance of apical/basal cell polarity positive regulation of multicellular organism growth filopodium assembly phosphatidylinositol-mediated signaling positive regulation of protein secretion actin filament bundle assembly establishment of endothelial barrier positive regulation of establishment of protein localization to plasma membrane regulation of organelle assembly terminal web assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process positive regulation of early endosome to late endosome transport leukocyte cell-cell adhesion membrane to membrane docking epithelial cell differentiation establishment of epithelial cell apical/basal polarity negative regulation of transcription from RNA polymerase II promoter cytoskeletal anchoring at plasma membrane axon guidance regulation of cell size protein kinase A signaling gland morphogenesis astral microtubule organization regulation of actin cytoskeleton organization cellular protein complex localization cortical microtubule organization negative regulation of T cell receptor signaling pathway establishment of centrosome localization negative regulation of ERK1 and ERK2 cascade cellular response to cAMP protein localization to cell cortex establishment of protein localization to plasma membrane negative regulation of interleukin-2 secretion regulation of NIK/NF-kappaB signaling negative regulation of p38MAPK cascade
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