Invitrogen

Phospho-DNMT1 (Ser154) Polyclonal Antibody

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View all (47) DNMT1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-DNMT1 (Ser154) Polyclonal Antibody

Product Details

PA5-12963

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Dot blot (DB)

1:500
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S154 of human Dnmt1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2293065

Target Information

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; Dnmt1; FLJ16293; MCMT; MGC104992

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Gene Aliases: ADCADN; AIM; CXXC9; DNMT; DNMT1; HSN1E; m.HsaI; MCMT

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UniProt ID: (Human) P26358

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Entrez Gene ID: (Human) 1786

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Function(s)
DNA binding double-stranded DNA binding RNA binding DNA (cytosine-5-)-methyltransferase activity protein binding zinc ion binding methyl-CpG binding DNA-methyltransferase activity protein domain specific binding estrogen receptor binding histone deacetylase binding unmethylated CpG binding DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter DNA methylation transcription, DNA-templated Ras protein signal transduction brain development aging response to heat response to toxic substance response to ionizing radiation maintenance of DNA methylation DNA methylation on cytosine within a CG sequence positive regulation of gene expression response to activity gene silencing covalent chromatin modification neuron differentiation response to caffeine response to estradiol response to lipopolysaccharide response to vitamin A response to testosterone cellular response to platelet-derived growth factor stimulus response to antidepressant regulation of cell proliferation DNA hypermethylation response to ethanol negative regulation of gene expression, epigenetic S-adenosylhomocysteine metabolic process S-adenosylmethioninamine metabolic process S-adenosylmethionine metabolic process positive regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation cellular response to amino acid stimulus cellular response to lead ion cellular response to transforming growth factor beta stimulus C-5 methylation of cytosine positive regulation of methylation-dependent chromatin silencing cellular response to nerve growth factor stimulus
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